silicone heart model heart failure

Scientists at the Royal College of Surgeons, Ireland and partners at the National College of Art and Design, Dublin, have developed a silicon heart model intended to model heart failure with preserved ejection fraction. Representing a “simulated circulatory loop”, this device contains simulated versions of the left atrium and left ventricle, with each ventricle independently controlled to model the entire cardiac cycle. Researchers use air pressure in the surrounding chamber to pump the device. This is much the same way the diaphragm controls breathing by changing the air pressure in the thoracic cavity. The researchers hope their model will help test a variety of tools aimed at treating heart failure, such as mechanical assist devices.

Heart failure is on the rise, especially in developing countries, and it is important to develop new treatments for this patient population. As part of that, we are developing new methods to test therapeutic interventions, including new medical devices. Researchers have removed hearts from experimental animals and tried to keep them beating for as long as possible in hopes of testing new treatments. and limits its usefulness.

It is also important to accurately model the type of heart failure you want to treat. In about half of heart failure cases, the left ventricular ejection fraction (a measure of the percentage of ventricular blood ejected with each beat) is largely preserved and remains above 50%.these nuances in vitro A heart removed from a pig is challenging. As a result, researchers have turned to synthetic heart models, and this latest one takes a leap forward by modeling both the left ventricle and the left atrium.

“Half of the patients presenting with heart failure have heart failure with preserved ejection fraction, and that number is increasing, especially in developed countries, due to the increasing prevalence of risk factors,” the study said. said Aamir Hameed, a researcher involved in “This condition can be difficult to treat with drugs and is causing a considerable strain on health services around the world. It is a milestone in heart failure research as it allows us to test devices that may treat conditions that affect us, improve quality of life and reduce the burden on health services.

The device can model healthy heart function, and by limiting diastolic relaxation and filling, it can also model heart failure with preserved ejection fraction. Interventions to treat this type of heart failure will likely need to target both the atrium and ventricle, making this technology an excellent platform for testing new therapeutic interventions.

“To date, no lab model has been developed with two independently controlled ventricles to mimic the cardiac cycle and fully simulate left atrial and left ventricular blood flow during the resting phase of the cardiac cycle. No,” said Andrew. Another researcher involved in this study, Malone. “This is an important step forward in developing a robust tool for testing heart failure device therapy.”

Research in journals The forefront of cardiovascular medicine: In Vitro Benchtop Simulated Circulatory Loop for Heart Failure Preserving Ejection Fraction Emulation

Via: Royal College of Surgeons, Ireland silicone heart model heart failure

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