Scientists Find New Ways to Predict the Efficacy of the COVID-19 Vaccine

Has been updated:
May 18, 2021 08:50 IST

Canberra [Australia]May 18 (ANI): Initial immune response of vaccinated individuals COVID-19 (new coronavirus infection) Analysis by Australian mathematicians, clinicians and scientists has made it possible to predict the level of protection against the virus in the long run and published Nature Medicine.
The researchResearchers at the Kirby Institute, Peter Doherty Institute for Infection and Immunity, University of New South Wales, and the University of Sydney vaccination protection.This can significantly reduce development time for new developments. vaccinationBy measuring neutralizing antibody levels as a “proxy” for immune protection from s, COVID-19 (new coronavirus infection)..
“Neutralizing antibodies are small Y-shaped proteins that our body produces in response to infections and vaccinations. They bind to the virus and reduce its ability to infect,” says Deborah of the Kirby Institute. Dr. Cromer says.
“We have long known that neutralizing antibodies are likely to be an important part of the immune response, COVID-19 (new coronavirus infection), I don’t know how much antibody is needed for immunity. Our study is the strongest evidence to date that certain antibody levels lead to higher levels of protection from disease. “
The researchers analyzed 7 data COVID-19 (new coronavirus infection) vaccination■ Investigate how the response measured immediately after vaccination correlates with protection. Then, statistical analysis was used to define a specific relationship between immune response and protection.Their analysis was very accurate and could predict the effectiveness of the new ones. vaccination..
Dr. Cromer said this finding could change our behavior. COVID-19 (new coronavirus infection) vaccination Future exams.
“Antibody immunity levels are much easier to measure than direct measurements. vaccination Effectiveness over time.So by measuring antibody levels across the new range vaccination Candidates in the early stages of clinical trials vaccination Must be used to prevent COVID-19 (new coronavirus infection).. “

Another important application of this analysis is the ability to predict immunity over time.The researchers predict its immunity COVID-19 (new coronavirus infection) Vaccination infections are significantly reduced within a year, and blood neutralizing antibody levels are reduced in the first few months after infection or vaccination.
“Vaccination is very effective in preventing both symptoms and serious illnesses in the short and medium term, but in most cases it is predicted to be less effective in the first few months. vaccination“S,” says Dr. David Corey, also at the Kirby Institute.
“But it is very important to understand the difference between immunity to infection and protection from the development of severe illness. In our study, the level of antibody required to protect against severe illness is 6 minutes. It turned out to be 1. In the first year after vaccination, you will start to lose immunity to mild infections, protection from severe infections should last long, “says Dr. Khoury.
“But ultimately, for optimal protection against moderate illness and infection. COVID-19 (new coronavirus infection)These findings suggest that we may be looking at each year vaccination Boosters, as in the case of the flu vaccination.. “
The major global challenges are the evolution of viruses and the emergence of new variants. Based on laboratory studies, there is growing concern that antibodies developed against the predominant strains are not very effective in neutralizing these new mutants.
“An additional benefit of our work is that we can predict how well the immune response will be protected against various variants,” said Jamie Trickus, a professor at the University of Sydney’s Mareeba Seal Institute and School of Medicine and Health. say.
“This analysis shows that there is a very good correlation between immune responses, which is very easy to test and vaccination To prevent infections that are very difficult to test. This means that large and costly clinical trials can predict the protection of the immune response against different variants without determining efficacy for each variant. (ANI) Scientists Find New Ways to Predict the Efficacy of the COVID-19 Vaccine

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