Reveal promising use cases for exosomes

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Extracellular vesicles, or more commonly known exosomes, continue to be the focus of curious research for the scientific community. Exosomes, once thought to be waste products secreted by cells, have recently been identified as mail carriers and play an important role in cell-to-cell communication by functioning as a means of delivery between cells. I am. A new study at Carnegie Mellon University and UPMC is exploring new use cases for exosomes. It is to provide growth factors such as bone morphogenetic protein (BMP) for bone healing.

Exosomes resemble nano-sized bubbles and are secreted by all cells in the body. Functionally, it conveys messages from one cell to another, such as proteins, DNA, RNA, and other biomolecules. cell It behaves and works. Simply put, if exosomes are produced by bad cells such as cancer cells, they carry a bad message, and conversely, if they are produced by healthy cells, they carry a good message. Exosomes are currently being studied as biomarkers and for a variety of therapeutically specialized applications.

Saigopalakrishna “Sai” Yerneni, a postdoctoral fellow at Carnegie Mellon University, said: University. “We focused our first efforts on one type Growth factors-BMP2. BMP2 designed exosomes can be used to help people with bone healing and traumatic bone injury. “

Growth factors as proteins have important effects in altering the behavior of cells and are usually locked. In other words, in order for growth factors to affect cell behavior or exert therapeutic effects, they must first bind to receptors on the surface of the cell. In the course of the group’s research, they discovered that when BMP2 was designed for exosomes, this locking and key mechanism could be bypassed.

“This may seem trivial at first, but this finding has the potential to change our current understanding of growth factor signaling processes,” said a professor of biomedical engineering. Phil Campbell, a member of the Engineering Research Accelerator, said.

To date, few growth factors have been approved for clinical use by the FDA. This is partly due to the generally high concentrations of growth factors required for the therapeutic effect of humans. However, BMP2 delivered via engineering exosomes has been found to produce therapeutic effects at very low concentrations. This discovery offers new hope for future clinical applications of exosome-mediated growth factor delivery.

“Beyond continuing to pursue the biological aspects of extracellular vesicles-Cell communication, Will be expanded again ExosomesA based delivery approach to other growth factors that may help control diseases such as regenerative medicine and cancer, “Campbell said.

Exosome Nanoporators: Nanofluid devices for developing exosome-based drug delivery vehicles

For more information:
Saigopalakrishna S. Yerneni et al, Regulation of cell transport and osteoblast formation by extracellular vesicle-related bone morphogenetic protein 2. Journal of extracellular vesicles (2021). DOI: 10.1002 / jev2.12155

Quote: Https: // Discovered Promising Use Cases for Exosomes Obtained November 29, 2021 (November 29, 2021)

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