Polymer brushes capture and release proteins on demand

Researchers at Chalmers University of Technology in Sweden have developed a “polymer brush” system that can capture and release proteins using electrical stimulation. Demand for protein therapeutics is increasing, but the efficient production of them remains a challenge. Separating therapeutic proteins from the fluids that surround the cells used to produce them in biotechnology processes is difficult and inefficient, but the researchers behind this state-of-the-art technology say that new technologies do this. We hope to form an efficient and gentle way to achieve it. In addition, another exciting application could be in sustained release devices that can deliver therapeutic proteins to diseased sites in the body in response to electrical signals. This can be started from outside the body, such as through a phone app.

Creating biomedicine, including protein therapy, can be very expensive. Part of the problem is the separation of proteins from the primitive soup they were made from. Chromatography is now used to bind and separate such proteins, which require harsh chemicals to re-release the proteins, damaging delicate proteins and reducing yields. increase. The researchers behind this latest innovation have created a reusable technology that can capture and release proteins hundreds of times.

“Our polymer surface provides a new way to separate proteins by using electrical signals to control how proteins are attached to and released from the surface without affecting the structure of the protein. “, Research.

This technique consists of polymer strands placed in a brush structure. A small electrical pulse allows the strand to initiate protein capture or release of a protein that has already been captured. Because this technology works in a biological environment, it may function in the body as a protein delivery device that can release therapeutic proteins with the touch of a button or smartphone screen.

“A doctor or computer program can imagine a remote control signal that measures a patient’s need for a new drug and activates the release of the drug from an implant in the required tissue or organ.”・ Del Castillo said. “We believe that the ability to control the release and uptake of proteins in the body with minimal surgical intervention without needle injection is a unique and useful property. The development of electronic implants has been for years. It’s just one of a few possible applications ahead. Research that helps connect electronics and biology at the molecular level is an important part of the puzzle in that direction. “

Study at Angewandte Chemie International Edition: An electrically switchable polymer brush for protein capture and release in a biological environment

Via: Chalmers University of Technology Polymer brushes capture and release proteins on demand

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