New Brain Research Offers Hope for Alzheimer’s Disease

Has been updated:
May 13, 2021 12:05 IST

Arizona [US]May 13 (ANI): In a new study, researchers brain -A condition characteristic of not only Alzheimer’s disease but also other neurodegenerative conditions.
The results of the new research are published in the latest issue of the journal Acta Neuropathologica.
The study focuses on a specific protein known as Rbbp7Its dysregulation appears to be associated with the final formation of tau protein tangles and rampant cell death associated with Alzheimer’s disease and other neurodegenerative diseases.
First, known as Amyloid plaqueIs a dense accumulation of misfolded amyloid proteins that occurs in the space between nerve cells.Most efforts to stop the progress of Alzheimer’s disease Targets amyloid protein plaques. To date, everything has encountered a depressed failure.
The second classic trait has not been scrutinized until recently. It is composed of string-like formations in the body of neurons and is produced by another important protein, tau. These are known as neurofibrillary tangles.
In a new study, researchers and colleagues at the Biodesign Institute’s ASU-Banner Center for Neurodegenerative Diseases investigated these entanglements. brain -A condition characteristic of not only Alzheimer’s disease but also other neurodegenerative conditions.
“I had a feeling that this protein was involved. Alzheimer’s diseaseEspecially because it is known that protein has decreased Alzheimer’s disease Post hoc analysis brain Tissue when compared to normal brains “. Nikhil Dave, lead author of the new study, said.
Studies have shown a correlation with decline Rbbp7 With neuronal loss associated with levels and increased entanglement brain Weight reduction Alzheimer’s diseased brains. Interestingly, cell loss and tangle formation Rbbp7 Restored to baseline level.
Findings open new avenues for research that may help develop effective treatments for Alzheimer’s disease With a wide range of tau-related pain commonly referred to as tauopathy, such as Pick disease, frontotemporal dementia, and traumatic brain Injury.
Hell attack
Alzheimer’s disease It remains one of the most mysterious diseases known in medicine. Its clinical symptoms appear secretly over the years and can be masked by the normal process of aging.If it takes command brain However, the progression of the disease is often rapid and unforgiving.
Patients can experience a tremendous range of symptoms, including confusion, disorientation, delusions, oblivion, aggression, agitation, and progressive loss of motor control.
Researchers are now by the time the first appearance of the disease is revealed Alzheimer’s disease Quietly devastated brain For decades, the calling card was usually left in the form of plaque or tangles.

Alzheimer’s disease The main cause of dementia remains, and aging is a major risk factor. The disease is on a terrifying upward trajectory as life expectancy has increased and other previously deadly illnesses can be treated even if they cannot be cured.Currently, 5.8 million people are suffering in the United States alone Alzheimer’s diseaseAccording to the Center for Disease Research, that number is expected to grow to 14 million by 2060.
Many other factors besides aging contribute to this complex disorder, from genetic predisposition to vascular distress such as diabetes and obesity. Lifestyle choices such as diet and exercise can also affect vulnerabilities. The disease usually afflicts people over the age of 65, but early-onset disorders can develop much earlier.
Genome 2.0
A new study looks at another area of ​​risk for neurodegenerative diseases, areas related to individual genes and how they are expressed. 3 billion letters DNA The codes that make up an individual’s genome remain fixed throughout life, and researchers now find that highly diverse and complex chemical messengers act on the genome. DNA And guide that action.
These known epigenetic changes can turn genes on and off and regulate the amount of protein produced by these genes. The early concepts of biology, which emphasize the static view of the fate of the genome, have been replaced by new pictures of life in which changes in the environment can have a significant impact on the behavior of our genes. Scientists are just beginning to learn the widespread effects of the epigenome on human health and disease.
In the current study brain The level of protein Rbbp7 Less what researchers detect after death brain Tissue of patients with Alzheimer’s disease.
One function of Rbbp7 It is to regulate gene expression.This is done by changing the interaction of DNA A protein known as histone, DNA Wind the thread like a thread.when DNA The thread is loosely wound around the histone spool and the cellular machine can read what is exposed. DNA It sends a message, transcribes it into mRNA, which is translated into the case of DNA The thread is tightly wrapped around the histone, DNA The gene is hidden from view and transcription may be partially or completely blocked, thereby reducing or abolishing protein expression. (ANI)
Researchers Rbbp7 When the level drops, the level of another protein known as p300 rises, causing post-translational modification of the tau protein known as acetylation. The effect of this is to separate tau protein from the cellular structure known as microtubules to which tau normally binds.The detached tau accumulates freely in neurons and eventually Alzheimer’s disease.. (Refer to the attached figure.)
Acetylation of tau caused by low Rbbp7 Increased tau phosphorylation further promotes tangle formation and subsequent neuronal loss. brain..
In a new study, transgenic mice showing tau pathology Rbbp7 Increased neuronal loss.Restore Rbbp7 Cognitive impairment remained, but these conditions were reversed to normal levels in mice.
Ramon Velazquez, the corresponding senior author of the new study, speculates that this is because the study covers only small subregions of the hippocampus. brain Areas related to cognition were still rampant in the formation of tangles. “We will investigate the global impact of overexpression. Rbbp7 Our future research will see if we can save learning, memory, and other cognitive aspects. “
Relationship outlined in the study between Rbbp7 Tangle formation of levels and tau, cell death and loss of cognitive function brain It is convincing.The results suggest that Rbbp7 Can be an attractive target for drug discovery and the development of effective therapies Alzheimer’s disease And other tau-related distress. Treatments based on this type of study may be ready for clinical trials within the next five years.
Nevertheless, the authors emphasize that other molecular players are likely to be involved in these complex processes.In future studies, researchers plan to perform extensive and unbiased probing of protein interactions, transcriptional pathways. DNA For epigenetic modifications that can lead to mRNA and neurodegenerative diseases. (ANI) New Brain Research Offers Hope for Alzheimer’s Disease

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