Cross the blood-brain barrier using a laser and gold nanoparticles

Delivery of the drug to the brain remains a challenge because of the blood-brain barrier, a special endothelial layer that is highly selective and allows it to the nervous tissue beyond. At the University of Texas at Dallas, researchers may develop technologies that allow therapeutic agents to cross the blood-brain barrier, enabling new treatments for brain tumors and other conditions that affect the brain.

In this method, gold nanoparticles are administered into the bloodstream and activated using transcranial laser illumination to create temporary openings in the tight junctions between the endothelial cells that line the cerebral blood vessels. When nanoparticles are placed near tight junctions, researchers use a very rapid burst of laser light to pass through the skull non-invasively and “activate” them into tight junctions. Apply a small mechanical force. This means that the barrier will become permeable for some time, allowing researchers to deliver different types of therapeutic agents to the brain.

So far, the UT Dallas team has tested the system for its ability to provide a variety of therapies such as antibodies, gene therapy, and liposomes, suggesting that this approach is extremely versatile.

“An approach to increase the blood-brain barrier [BBB] Permeability is essential for advancing treatments for CNS disorders, “said Xiaoqing Li, a researcher involved in the study, through a press release. “This action creates a small mechanical force that temporarily opens the barrier and allows the drug to enter the bloodstream to the brain.”

So far, the UT Dallas team has shown that this technology does not appear to be harmful and can offer a variety of treatments. More research will be needed, but new technologies may prove to be very important in making new therapies available for brain conditions.

“We have demonstrated that BBB permeability can be regulated without significant disruption of spontaneous vasomotor or neurovascular unit structure,” said Dr. Chikai, another researcher involved in the study. I am.

Study at Nano letter: Reversible regulation of the blood-brain barrier by laser stimulation of molecular-targeted nanoparticles

via: University of Texas at Dallas Cross the blood-brain barrier using a laser and gold nanoparticles

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