Advanced multi-organ chip for personalized medicine

Researchers at the University of Columbia’s Faculty of Engineering and Applied Science have developed an advanced Organ-on-a-chip system that incorporates heart, bone, liver, and skin tissue into an independent niche linked to simulated vascular flow. bottom. The system also contains immune cells that circulate within the simulated vascular system. This technique represents advances in the Organ-on-a-chip system, allowing scientists to study the effects of drugs and interventions on multiple organs simultaneously. In addition, all artificial tissues are created using induced pluripotent stem cells derived from blood samples, which may enable personalized medicine.

Many research institutes around the world are developing a variety of unique devices, but creating multi-organ systems remains difficult. After all, each organ in the body enjoys the most suitable and unique environment, even though it is connected to other organs by circulation. Recreating these niches on the chip and allowing communication between them is a daunting task, but these researchers seem to have cracked it after a lot of hard work.

“This is a big achievement for us. For 10 years, we have run hundreds of experiments, explored countless great ideas, built many prototypes, and finally the interaction of organs. We have developed this platform that captures biology well, says Gordana Vunjak-Novakovic, one of the developers of the new platform.

The tip is the size of a microscope slide and contains bone, skin, heart, and liver tissue. Researchers chose this because all of these tissues experience significant side effects during cancer treatment. Therefore, this system represents a way to test whether a particular patient can tolerate a particular cancer treatment.

“Providing communication between organizations while maintaining individual phenotypes was a major challenge,” said Kacey Ronaldson-Bouchard, another researcher involved in the study. “We focus on using patient-derived tissue models, so each tissue needs to mature individually to function to mimic the response seen in the patient. Connect multiple tissues. Sometimes I don’t want to sacrifice this advanced feature. “

“In the body, each organ maintains its own environment while interacting with other organs through the flow of blood vessels that carry circulating cells and bioactive factors. Therefore, we connect tissues by vascular circulation. We chose, but maintained the individual tissue niche needed to maintain its biological fidelity and mimicked the way our organs are connected within the body. “

Study at Nature Biomedical Engineering: Multi-organ chip with mature tissue niche linked by vascular flow

Via: Columbia University Advanced multi-organ chip for personalized medicine

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